Fmoc-PEG4-Val-Ala-PAB-PNP from AXISPHARM is a cleavable antibody-drug conjugate (ADC) linker with an Fmoc-protected amine. The Val-Ala peptide is specifically cleaved by Cathepsin B. The Fmoc group can be deprotected under basic conditions to give the free amine, which can be used for further coupling. PNP is a good leaving group.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
