Sulfo DBCO-PEG4-TFP ester is a water-soluble, amine-reactive reagent that enables simple and efficient incorporation of DBCO moiety onto proteins, peptides or other amine-containing molecules. The hydrophilic sulfonated spacer arm greatly improves water solubility of DBCO derivatized molecules, in many cases making it completely soluble in aqueous media. The hydrophilic PEG spacer arm improves labeling efficiency and provides a long and flexible connection.
Sulfo DBCO-PEG4-TFP ester contains a sulfo group (-SO3-) and a cyclooctyne functional group, known as dibenzocyclooctyne (DBCO), attached to a PEG chain through a tetrafluorophenyl (TFP) ester linker. The sulfo group enables the compound to be highly water-soluble, while the DBCO group allows for the bioorthogonal conjugation of biomolecules.
Sulfo DBCO-PEG4-TFP ester has been extensively utilized in pharmaceutical research and development for the synthesis of bioconjugates. Its unique chemical properties allow for the site-specific and efficient conjugation of biomolecules, such as proteins, antibodies, and nucleic acids, to other molecules, such as drugs or imaging agents, via click chemistry. This bioorthogonal conjugation strategy offers numerous advantages over traditional conjugation methods, including high specificity, low background, and minimal interference with biological processes.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
