Methylcyclopropene-L-lysine (CAS: 1610703-09-7): Overview and Applications
Product Summary
Methylcyclopropene-L-lysine, also known as N-cyclopropene-L-lysine or CypK, is a lysine derivative featuring a cyclopropene group. This compound is used in bioorthogonal chemistry, where its cyclopropene moiety acts as a small, highly reactive handle for conjugation. It undergoes rapid inverse-electron-demand Diels-Alder reactions with tetrazine derivatives, making it ideal for creating stable, targeted bioconjugates.
Applications of Methylcyclopropene-L-lysine
- Antibody-Drug Conjugates (ADCs)
- Enables targeted drug attachment to antibodies for precise therapeutic delivery.
- Site-Specific Protein Labeling
- Allows site-specific incorporation into proteins through genetic code expansion for labeling and tracking.
- Targeted Drug Delivery
- Facilitates conjugation with therapeutic agents, improving delivery precision to specific cells or tissues.
- Bioorthogonal Chemistry
- Serves as a minimal bioorthogonal handle, enabling rapid conjugation with tetrazines in biological systems.
- Therapeutic Protein Conjugation
- Enhances the stability and efficacy of protein-based therapeutics, making it valuable for advanced drug development.
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