m-PEG3-acid chloride
This product is a monofunctional PEG reagent containing a three-unit PEG chain capped with a methyl group and terminated with a reactive acid chloride. The acid chloride specifically enables rapid coupling with amines, alcohols, or thiols to form stable amide, ester, or thioester linkages. The PEG3 spacer provides hydrophilicity and moderate flexibility, making this reagent an especially versatile intermediate for PEGylation, polymer modification, and bioconjugation.
Key Features and Benefits
-
Acid Chloride Group: Highly reactive toward amines, alcohols, and thiols.
-
PEG3 Spacer: Adds hydrophilicity and reduces steric hindrance.
-
Monomethyl Capping: Ensures single reactive site, preventing crosslinking.
-
Versatile Reactivity: Supports multiple conjugation pathways.
-
High Purity: Produced to ≥95% purity for reproducible results.
Applications
-
Bioconjugation: Couples PEG chains to proteins, peptides, or nanoparticles.
-
PEGylation: Improves solubility and stability of biomolecules or therapeutics.
-
Polymer Chemistry: Functionalizes polymers and hydrogels with PEG units.
-
Organic Synthesis: Serves as a versatile intermediate for custom linker design.
Storage and Handling
-
Storage: Store at –20 °C in a tightly sealed, moisture-free container.
-
Handling: Use under anhydrous conditions; reacts rapidly with nucleophiles.
This product combines PEG solubility with high reactivity, specifically providing a compact, efficient reagent for PEGylation and bioconjugation workflows.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
