Trityl-PEG8-azide
This product is a heterobifunctional PEG linker featuring a terminal azide for click chemistry and a trityl-protected hydroxyl group. The PEG8 spacer provides excellent solubility and steric flexibility, making it especially valuable for orthogonal synthesis, bioconjugation, and drug delivery applications.
Key Features and Benefits:
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Azide Group: Enables CuAAC or SPAAC click chemistry with alkynes.
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Trityl Protection: Acid-labile protecting group for stepwise synthesis.
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PEG8 Spacer: Enhances solubility, hydrophilicity, and steric accessibility.
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Orthogonal Design: Supports controlled, multi-step conjugation.
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High Purity: Ensures reproducible performance in advanced workflows.
Applications:
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Bioconjugation: Facilitates orthogonal functionalization of biomolecules.
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Drug Delivery: Provides PEGylated scaffolds with click-ready functionality.
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Probe Development: Builds multifunctional probes with controlled protection.
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Synthetic Chemistry: Serves as an intermediate for advanced linker design.
Storage and Handling:
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Storage: Store at –20 °C in a tightly sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid premature trityl deprotection.
This product integrates click-ready azide functionality with a trityl-protected hydroxyl group in a PEG8 scaffold, specifically enabling solubility, flexibility, and orthogonal reactivity for complex synthetic applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
