Trityl-PEG10-azide
This high-purity PEG linker features an azide for CuAAC or SPAAC click chemistry and a trityl-protected thiol specifically for selective deprotection under mild acidic conditions. The PEG10 spacer improves solubility, flexibility, and reduces steric hindrance, enabling especially efficient orthogonal bioconjugation in aqueous and organic systems.
Key Features and Benefits
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Azide Group – Enables CuAAC or SPAAC click chemistry with alkynes for stable triazole linkage formation
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Trityl-Protected Thiol – Allows controlled thiol release for site-specific conjugation
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PEG10 Spacer – Improves solubility, flexibility, and accessibility of reactive groups
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Orthogonal Reactivity – Supports sequential modifications without cross-reactivity
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High Purity – Supplied at >95% purity for reliable and reproducible results
Applications
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Dual-functional linker for orthogonal bioconjugation
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Protein, peptide, and small molecule modification
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Antibody–drug conjugate (ADC) synthesis
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Multifunctional probe and biosensor development
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light
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Handling: Use anhydrous solvents such as DMSO or DMF; avoid prolonged exposure to moisture and acidic conditions unless deprotection is intended
This product features an azide for click chemistry and a trityl-protected thiol, linked by a PEG10 spacer specifically for solubility, flexibility, and efficient orthogonal bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
