Tri(Amino-PEG3-amide)-amine TFA salt

Tri(Amino-PEG3-amide)-amine (CAS 2055040-99-6): Key Compound for Bioconjugation and Drug Delivery

Overview:
Tri(Amino-PEG3-amide)-amine, CAS 2055040-99-6, has a central amine group and three PEG3 chains capped with amide bonds. Its structure offers high reactivity, making it ideal for applications in bioconjugation, drug delivery, and nanotechnology.

Core Features:

1. Tri(amine) Group:
   Three amino (-NH₂) groups react quickly with carboxylic acids, forming amide bonds. Coupling agents like HATU, EDC, and DCC enhance these reactions, perfect for peptide synthesis.
2. PEG3 Chain:
   The PEG3 chains increase solubility and biocompatibility. PEGylation reduces immunogenicity, extending the molecule’s circulation time.

Applications:

• Bioconjugation:
  Amine groups form stable amide bonds, essential for attaching biomolecules like antibodies and peptides.
• Reductive Amination:
  Amine groups react with carbonyl compounds, creating C-N bonds important for drug targeting.
• Amide Bond Formation:
  Carboxylic acids can form stable amide bonds with primary amines using coupling agents, supporting polymer synthesis.

Key Benefits:

• Solubility and Stability:
  PEG3 chains enhance solubility and protect bioactive molecules.
• Reduced Immunogenicity:
  PEGylation decreases immune response, ideal for therapeutic use.
• Versatility:
  Reactivity with both amines and carboxyl groups allows multiple chemical modifications.

In summary, Tri(Amino-PEG3-amide)-amine offers high reactivity and stability for bioconjugation, drug delivery, and nanotechnology, making it invaluable for advanced biotech research.