Tri(Amino-PEG3-amide)-amine (CAS 2055040-99-6): Key Compound for Bioconjugation and Drug Delivery
Overview:
Tri(Amino-PEG3-amide)-amine, CAS 2055040-99-6, has a central amine group and three PEG3 chains capped with amide bonds. Its structure offers high reactivity, making it ideal for applications in bioconjugation, drug delivery, and nanotechnology.
Core Features:
- Tri(amine) Group:
Three amino (-NH₂) groups react quickly with carboxylic acids, forming amide bonds. Coupling agents like HATU, EDC, and DCC enhance these reactions, perfect for peptide synthesis. - PEG3 Chain:
The PEG3 chains increase solubility and biocompatibility. PEGylation reduces immunogenicity, extending the molecule’s circulation time.
Applications:
- Bioconjugation:
Amine groups form stable amide bonds, essential for attaching biomolecules like antibodies and peptides. - Reductive Amination:
Amine groups react with carbonyl compounds, creating C-N bonds important for drug targeting. - Amide Bond Formation:
Carboxylic acids can form stable amide bonds with primary amines using coupling agents, supporting polymer synthesis.
Key Benefits:
- Solubility and Stability:
PEG3 chains enhance solubility and protect bioactive molecules. - Reduced Immunogenicity:
PEGylation decreases immune response, ideal for therapeutic use. - Versatility:
Reactivity with both amines and carboxyl groups allows multiple chemical modifications.
In summary, Tri(Amino-PEG3-amide)-amine offers high reactivity and stability for bioconjugation, drug delivery, and nanotechnology, making it invaluable for advanced biotech research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
