THP-SS-PEG1-t-butyl ester
This product is a protected PEG linker containing a tetrahydropyranyl (THP) group, a cleavable disulfide (SS) bond, a short PEG1 spacer, and a terminal t-butyl ester. The THP group provides stability for hydroxyl protection, while the disulfide linkage enables reductive cleavage. The PEG1 spacer specifically improves solubility and flexibility, and the t-butyl ester allows deprotection to yield a free carboxylic acid for further functionalization.
Key Features and Benefits
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THP Protection: Protects hydroxyl groups during synthesis, removable under mild acidic conditions.
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Disulfide Linker (SS): Provides cleavable functionality for controlled release under reductive environments.
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PEG1 Spacer: Improves solubility and reduces steric hindrance in conjugation workflows.
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t-Butyl Ester: Protects carboxyl groups until selective deprotection is desired.
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High Purity: Manufactured to ≥95% purity for reliable synthetic performance.
Applications
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Bioconjugation: Serves as a protected intermediate for cleavable linkers in biomolecule labeling.
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Drug Delivery Research: Enables construction of redox-sensitive delivery systems.
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Probe Development: Builds cleavable probes for imaging and chemical biology.
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Organic Synthesis: Provides a multifunctional protected PEG linker for advanced synthetic strategies.
Storage and Handling
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Storage: Store at –20 °C in a tightly sealed container, protected from moisture and light.
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Handling: Use under inert conditions when possible; remove protecting groups with standard deprotection methods.
This product integrates THP and t-butyl protections with a cleavable disulfide bond, specifically offering a versatile intermediate for redox-sensitive bioconjugation and synthetic chemistry.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
