Thiol-PEG6-t-butyl ester
This product is a high-purity PEG linker with a terminal thiol and a tert-butyl ester, specifically connected by a PEG6 spacer for solubility and flexibility.
Key Features and Benefits
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Thiol Group – Enables selective conjugation to maleimides, acrylates, or activated halides.
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tert-Butyl Ester – Cleavable under mild acidic conditions to yield a free carboxylic acid for further functionalization.
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PEG6 Spacer – Provides hydrophilicity, reduced steric hindrance, and improved accessibility in bioconjugation.
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High Purity – Suitable for controlled conjugation, surface modification, and polymer–drug conjugates.
Applications
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Dual-functional linker for bioconjugation and surface chemistry
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Synthesis of thiol- and carboxyl-functionalized biomolecules
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PEGylation of proteins, peptides, or nanoparticles
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Building block for drug delivery, materials science, and diagnostics
Storage & Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Use: Dissolve in anhydrous solvents (e.g., DMF, DMSO, dichloromethane). Avoid repeated freeze–thaw cycles.
This product provides a thiol and a tert-butyl ester on a PEG6 spacer, enabling versatile conjugation strategies, acid generation, and improved solubility specifically for bioconjugation and material applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
