Thiol-PEG6-acid (CAS 1347750-77-9) is a bifunctional polyethylene glycol (PEG) linker with a thiol (-SH) group on one end and a carboxylic acid (-COOH) group on the other. This structure supports the creation of stable, hydrophilic conjugates through thiol-disulfide exchange or thiol-maleimide click chemistry.
Key Features:
- Molecular Formula: C₁₅H₃₀O₈S
- Molecular Weight: 370.46 g/mol
- Functional Groups: Thiol (-SH) and carboxylic acid (-COOH)
- Solubility: Highly soluble in water and organic solvents
Applications:
- Bioconjugation:
- Thiol groups form covalent bonds with maleimide molecules or disulfides for biomolecule attachment.
- Carboxylic acids react with amines to form stable amide bonds.
- Drug Delivery:
- Acts as a linker for PEGylated bioconjugates, improving solubility, stability, and bioavailability for targeted and controlled drug release.
- PROTAC Development:
- Serves as a linker for proteolysis-targeting chimeras (PROTACs), facilitating selective protein degradation.
Thiol-PEG6-acid is a valuable tool for pharmaceutical research, enabling the development of advanced therapeutics and biomolecular systems.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
