Thiol-(CH2)6-O-PEG8-acid
This product is a heterobifunctional linker containing a terminal thiol, a hexamethylene (C6) spacer, an eight-unit PEG chain, and a terminal carboxylic acid. The thiol enables selective conjugation with maleimides or disulfide exchange, while the carboxyl group couples efficiently with amines for stable amide bond formation. The PEG8 spacer specifically enhances solubility and flexibility, and the C6 segment adds hydrophobic spacing for controlled orientation in conjugates.
Key Features and Benefits
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Terminal Thiol: Reacts with maleimides or forms disulfides.
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Carboxylic Acid Group: Couples with amines to create stable amide linkages.
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PEG8 Spacer: Improves water solubility and provides flexibility.
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C6 Spacer: Adds hydrophobic distance for tailored conjugation geometry.
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High Purity: Produced to ≥95% purity for reproducible applications.
Applications
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Bioconjugation: Links thiol- and amine-containing biomolecules.
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Drug Delivery: Serves as a linker for PEGylated therapeutics with dual reactivity.
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Protein and Antibody Labeling: Supports controlled, site-specific modifications.
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Probe Development: Builds multifunctional probes for imaging and diagnostics.
Storage and Handling
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Storage: Store at –20 °C in a sealed, desiccated container.
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Handling: Use freshly prepared solutions; avoid repeated freeze–thaw cycles.
This product combines thiol and carboxyl reactivity with PEG solubility and hydrophobic spacing, making it an especially versatile tool for bioconjugation, probe design, and therapeutic research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
