Thalidomide-O-PEG5-Tosyl
This product is a heterobifunctional linker containing a thalidomide moiety, a PEG5 spacer, and a terminal tosyl (p-toluenesulfonyl) group. The thalidomide unit binds cereblon (CRBN), making it especially valuable in PROTAC and molecular glue design. The PEG5 spacer improves solubility, flexibility, and accessibility, while the tosyl group functions as an excellent leaving group for substitution with nucleophiles such as amines, thiols, or alkoxides.
Key Features and Benefits
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Thalidomide Moiety: Binds CRBN E3 ligase for targeted protein degradation.
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Tosyl Group: Provides a reactive leaving group for substitution chemistry.
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PEG5 Spacer: Adds solubility, flexibility, and reduces steric hindrance.
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Multifunctional Design: Supports both PROTAC development and synthetic modifications.
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High Purity: Produced to ≥95% purity for reproducible results.
Applications
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PROTAC Development: Links thalidomide to ligands for targeted protein degradation.
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Medicinal Chemistry: Serves as a modular intermediate in drug discovery.
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Probe Development: Builds CRBN-binding probes for mechanistic studies.
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Bioconjugation: Enables nucleophilic substitution reactions for custom conjugates.
Storage and Handling
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Storage: Store at –20 °C in a sealed, desiccated container.
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Handling: Protect from moisture; tosyl groups are reactive toward nucleophiles.
This product combines CRBN-binding, PEG solubility, and tosyl reactivity, specifically offering a versatile scaffold for targeted degradation research and synthetic applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.