Thalidomide-O-PEG4-t-butyl ester
This product is a heterobifunctional linker that integrates thalidomide for E3 ligase binding with a PEG4 spacer and a t-butyl ester as an acid-labile protecting group. This design specifically provides solubility, controlled deprotection, and optimal spacing, making it highly useful in PROTAC synthesis, drug discovery, and bioconjugation.
Key Features and Benefits:
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Thalidomide Moiety: Targets cereblon (CRBN) for PROTAC applications.
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t-Butyl Ester: Acid-labile protection allows orthogonal synthesis strategies.
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PEG4 Spacer: Enhances solubility, hydrophilicity, and steric flexibility.
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Multifunctional Design: Combines CRBN recruitment with protected linker chemistry.
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High Purity: Ensures reproducibility in drug discovery and research workflows.
Applications:
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PROTAC Development: Serves as a CRBN ligand with protected carboxyl handle.
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Drug Discovery: Supports linker optimization in targeted protein degradation.
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Bioconjugation: Provides orthogonal functional handles for stepwise synthesis.
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Chemical Biology: Enables design of thalidomide-based tools and probes.
Storage and Handling:
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Storage: Store at –20 °C in a sealed, moisture- and light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid premature t-butyl ester cleavage.
This product combines CRBN-binding thalidomide with PEG spacing and an acid-labile ester, offering an especially versatile building block for PROTACs and advanced bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.