Thalidomide-O-amido-PEG4-propargyl
This product is a heterobifunctional linker combining thalidomide for cereblon (CRBN) E3 ligase recruitment with a PEG4 spacer and a terminal propargyl group for click chemistry. This design specifically offers solubility, spacing, and bioorthogonal reactivity, making it highly effective in PROTAC synthesis, drug discovery, and bioconjugation.
Key Features and Benefits:
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Thalidomide Moiety: Binds CRBN for targeted protein degradation in PROTACs.
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Propargyl Group: Enables CuAAC or SPAAC click chemistry with azides.
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PEG4 Spacer: Provides solubility, hydrophilicity, and steric accessibility.
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Multifunctional Design: Combines CRBN targeting with bioorthogonal reactivity.
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High Purity: Ensures reproducibility in drug discovery and research workflows.
Applications:
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PROTAC Development: Links ligands for targeted protein degradation.
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Drug Discovery: Provides a versatile intermediate for modular synthesis.
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Probe Development: Builds bioorthogonal, thalidomide-based imaging probes.
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Bioconjugation: Combines E3 ligase recruitment with click chemistry handles.
Storage and Handling:
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); protect propargyl group from oxidative degradation.
This product merges CRBN-binding thalidomide with a click-ready alkyne in a PEG4 scaffold, making it an especially versatile building block for PROTACs and advanced bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
