Tetrazine-SSPy is a cleavable heterobifunctional linker designed for advanced bioconjugation. It combines a methyltetrazine moiety, ideal for inverse electron demand Diels-Alder (IEDDA) reactions, with an activated thiol for forming disulfide bonds. This innovative linker is fast, selective, and highly compatible with complex biological systems, making it perfect for cutting-edge research and therapeutic applications.
Key Features
- Fast and Specific Reactions
- Reacts rapidly with strained alkenes like trans-cyclooctene (TCO), norbornene, and cyclopropene.
- Forms stable and reliable dihydropyridazine linkages.
- Activated Thiol Group
- Enables disulfide bond formation for controlled cleavage.
- High Bioorthogonal Selectivity
- Functions selectively in complex biological systems without interfering with other processes.
- Biocompatible and Versatile
- Works seamlessly in aqueous solutions and even within living organisms.
Tetrazine-SSPy Applications
- Fluorescent Imaging
- Enables precise visualization of biomolecules in cells and tissues.
- Targeted Drug Delivery
- Supports the development of drugs that release in specific environments.
- PET and SPECT Imaging
- Ideal for radiotracer labeling in medical diagnostics.
- Drug Target Identification
- Helps researchers pinpoint and study new therapeutic targets.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
