TCO-PEG8-TFP ester
This product is a heterobifunctional linker featuring a trans-cyclooctene (TCO) group for ultrafast tetrazine ligation and a tetrafluorophenyl (TFP) ester for efficient amine conjugation. The PEG8 spacer specifically enhances solubility, flexibility, and steric accessibility, making it highly effective for bioorthogonal labeling, probe development, and ADC design.
Key Features and Benefits:
-
TCO Group: Enables rapid, copper-free IEDDA ligation with tetrazines.
-
TFP Ester: Couples efficiently with primary amines under mild conditions.
-
PEG8 Spacer: Improves solubility, hydrophilicity, and steric spacing.
-
Dual Reactivity: Combines bioorthogonal click chemistry with amine coupling.
-
High Purity: Ensures reproducibility in advanced workflows.
Applications:
-
Bioorthogonal Labeling: Provides rapid, catalyst-free conjugation with tetrazines.
-
ADC Development: Builds long-chain PEGylated antibody–drug conjugates.
-
Probe Development: Constructs multifunctional probes for imaging and diagnostics.
-
Drug Delivery: Enhances solubility and circulation in therapeutic conjugates.
Storage and Handling:
-
Storage: Store at –20 °C in a sealed, moisture- and light-protected container.
-
Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid hydrolysis of the TFP ester.
This product combines rapid TCO–tetrazine ligation with amine-reactive TFP chemistry in a PEG8 scaffold, specifically offering versatility for conjugation, drug delivery, and probe development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
