TCO-PEG8-TCO
This product is a homobifunctional PEG linker containing two trans-cyclooctene (TCO) groups connected by a PEG8 spacer. It enables rapid tetrazine click chemistry while providing solubility and medium-length spacing for versatile bioconjugation and materials applications.
Key Features and Benefits
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Dual TCO Groups: React rapidly with tetrazines via IEDDA click chemistry.
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PEG8 Spacer: Provides solubility, flexibility, and medium-length spacing.
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Homobifunctional Design: Enables symmetric crosslinking of tetrazine-modified molecules.
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Copper-Free Chemistry: Suitable for biological systems without cytotoxic catalysts.
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High Purity: Ensures reproducibility in sensitive workflows.
Applications
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Bioconjugation: Crosslinks tetrazine-modified proteins, peptides, or biomolecules.
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Probe Development: Builds multifunctional probes for imaging and diagnostics.
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Drug Delivery: Provides PEG scaffolds with dual click handles.
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Material Science: Functionalizes nanoparticles, polymers, and hydrogels with click-ready groups.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.
This product integrates dual TCO groups with a PEG8 spacer, specifically offering solubility and reactivity for efficient bioorthogonal crosslinking and conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
