TCO-PEG7-amine
This product is a heterobifunctional linker containing a trans-cyclooctene (TCO) group, a PEG7 spacer, and a terminal primary amine. The TCO enables ultrafast copper-free click chemistry with tetrazines, while the amine group couples readily with carboxyls or activated esters. The PEG7 spacer specifically enhances solubility and flexibility, reducing steric hindrance in conjugation.
Key Features and Benefits
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TCO Group: Provides rapid copper-free click ligation with tetrazines via IEDDA chemistry.
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Primary Amine: Couples efficiently with carboxylic acids and NHS esters.
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PEG7 Spacer: Improves aqueous solubility, flexibility, and bioconjugation efficiency.
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Dual Reactivity: Supports orthogonal conjugation strategies.
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High Purity: Manufactured to ≥95% purity for reproducible performance.
Applications
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Bioconjugation: Couples biomolecules using amide bond formation and TCO–tetrazine ligation.
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Protein and Antibody Labeling: Provides selective functionalization via lysine or carboxyl groups.
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Probe Development: Builds dual-reactive probes for imaging and diagnostics.
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Drug Delivery: Functions as a linker for PEGylated therapeutics and targeted carriers.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Dissolve freshly before use; avoid repeated freeze–thaw cycles.
This product integrates ultrafast click chemistry with a reactive amine terminus on a solubilizing PEG7 chain, making it an especially excellent tool for advanced bioconjugation and probe development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
