TCO-PEG7-acid
This product is a heterobifunctional linker containing a trans-cyclooctene (TCO) group, a PEG7 spacer, and a terminal carboxylic acid. The TCO moiety enables ultrafast copper-free click chemistry with tetrazines, while the carboxyl group allows amide bond formation with primary amines. The PEG7 chain specifically improves solubility, flexibility, and spacing, reducing steric hindrance in conjugation workflows.
Key Features and Benefits
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TCO Group: Provides rapid, copper-free reactivity with tetrazines through inverse electron-demand Diels–Alder (IEDDA) chemistry.
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PEG7 Spacer: Enhances solubility, flexibility, and reduces steric hindrance for efficient conjugation.
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Carboxylic Acid Group: Allows amide coupling with amines for versatile derivatization.
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Bioorthogonal Reactivity: Supports selective conjugation under physiological conditions without metal catalysts.
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High Purity: Manufactured to ≥95% purity for reliable and reproducible performance.
Applications
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Bioconjugation: Couples biomolecules via TCO–tetrazine ligation or amide bond formation.
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Drug Delivery: Serves as a linker for PEGylated therapeutics and targeted nanocarriers.
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Probe Development: Builds imaging and diagnostic probes with TCO functionality.
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Chemical Biology: Enables orthogonal labeling strategies in living systems.
Storage and Handling
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Storage: Store at –20 °C in a sealed container, protected from light and moisture.
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Handling: Dissolve freshly before use; avoid repeated freeze–thaw cycles.
This product integrates TCO click chemistry with a carboxyl group and solubilizing PEG7 spacer, making it an especially excellent linker for bioconjugation, probe development, and drug delivery applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
