TCO-PEG6-amine

TCO-PEG6-amine, TCO-PEG6-NH2, (CAS 2353409-94-4) is a bifunctional reagent featuring a trans-cyclooctene (TCO) moiety and a terminal amine group, connected by a six-unit polyethylene glycol (PEG6) spacer. This structure facilitates efficient bioconjugation and click chemistry applications.

Key Features:

• Molecular Formula: C₂₃H₄₄N₂O₈
• Molecular Weight: 476.60 g/mol
• Solubility: Highly soluble in water and organic solvents
• Functional Groups: TCO moiety and primary amine

Applications:

1. Bioconjugation:
   • The amine group reacts with activated esters or carboxylic acids to form stable amide bonds, enabling the attachment of biomolecules.
2. Click Chemistry:
   • The TCO moiety participates in rapid and selective inverse electron-demand Diels-Alder reactions with tetrazines, facilitating bioorthogonal labeling.
3. PROTAC Development:
   • Serves as a linker in the synthesis of proteolysis-targeting chimeras (PROTACs) for targeted protein degradation.

TCO-PEG6-NH2 is a versatile tool in chemical biology and drug discovery, offering efficient conjugation and labeling capabilities.

Ref:

1. Zhu, Y., 2022. Microfluidic Generation of Viscoelastic Artificial Antigen Presenting Cells for T Cell Activation. University of California, Los Angeles.

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