TCO-PEG6-amine

TCO-PEG6-amine is a specialized chemical reagent that includes a trans-cyclooctene (TCO) moiety and a free amine end group. This compound is designed for use in bioconjugation applications, particularly for linking with carboxyl acid-bearing biomolecules. The resulting TCO tag can subsequently be conjugated with tetrazine-bearing biomolecules through TCO-tetrazine ligation. This ultrafast bioorthogonal reaction is widely utilized in antibody-drug conjugates (ADCs) and various other conjugation applications, offering precise and efficient labeling and linking capabilities.

Ref:

1. Zhu, Y., 2022. Microfluidic Generation of Viscoelastic Artificial Antigen Presenting Cells for T Cell Activation. University of California, Los Angeles.

AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.