TCO-PEG5-maleimide
This product is a bifunctional PEG linker containing a trans-cyclooctene (TCO) group, a PEG5 spacer, and a maleimide group. It enables fast tetrazine click chemistry and selective thiol conjugation, specifically offering dual reactivity for advanced bioconjugation and probe development.
Key Features and Benefits
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TCO Group: Reacts rapidly with tetrazines via inverse-electron-demand Diels–Alder (IEDDA) chemistry.
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Maleimide Group: Couples selectively with thiols to form stable thioether bonds.
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PEG5 Spacer: Enhances solubility and reduces steric hindrance.
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Dual Functionality: Combines click and thiol chemistry in one linker.
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High Purity: Provides reliable and reproducible results.
Applications
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Bioconjugation: Links thiol-containing biomolecules with tetrazine-functionalized partners.
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Probe Development: Builds dual-reactive probes for imaging and diagnostics.
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Drug Delivery: Serves as a PEGylated scaffold with orthogonal reactivity.
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Material Science: Functionalizes polymers and nanostructures with bioorthogonal handles.
Storage and Handling
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Storage: Keep at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO to maintain reactivity.
This product combines TCO–tetrazine click reactivity with maleimide–thiol conjugation in a PEG5 scaffold, making it an especially powerful linker for bioconjugation and therapeutic development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
