TCO-PEG3-CH2-ald
This product is a bifunctional PEG linker containing a trans-cyclooctene (TCO) group, a PEG3 spacer, and a terminal aldehyde. It enables rapid tetrazine click chemistry and selective aldehyde conjugation, making it an especially versatile tool for bioconjugation and probe development.
Key Features and Benefits
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TCO Group: Reacts rapidly with tetrazines via inverse-electron-demand Diels–Alder (IEDDA) click chemistry.
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Aldehyde Group: Couples with amines or hydrazides to form stable linkages.
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PEG3 Spacer: Enhances solubility and reduces steric hindrance.
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Dual Reactivity: Combines click chemistry with aldehyde condensation.
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High Purity: Provides reproducibility in sensitive conjugation workflows.
Applications
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Bioconjugation: Links aldehyde-reactive and tetrazine-modified biomolecules.
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Probe Development: Builds dual-functional probes for diagnostics and imaging.
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Drug Delivery: Serves as a scaffold for PEGylated therapeutic conjugates.
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Material Science: Functionalizes surfaces and nanostructures with orthogonal chemistries.
Storage and Handling
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Storage: Keep at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.
This product integrates TCO click chemistry with aldehyde reactivity in a PEG3 scaffold, specifically offering a compact and versatile linker for bioconjugation and material science.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
