TCO-PEG12-TFP ester
This product is a heterobifunctional linker featuring a trans-cyclooctene (TCO) group for ultrafast tetrazine ligation and a tetrafluorophenyl (TFP) ester for efficient amine coupling. The PEG12 spacer provides excellent solubility, flexibility, and extended spacing, making it especially valuable for probe design, ADCs, and drug delivery.
Key Features and Benefits:
-
TCO Group: Enables rapid, copper-free IEDDA click chemistry with tetrazines.
-
TFP Ester: Couples efficiently with primary amines to form stable amide bonds.
-
PEG12 Spacer: Provides hydrophilicity, solubility, and long steric separation.
-
Dual Reactivity: Combines bioorthogonal and amine-targeted chemistry.
-
High Purity: Ensures reproducibility in advanced workflows.
Applications:
-
ADC Development: Provides PEGylated scaffolds for targeted drug delivery.
-
Probe Development: Builds TCO-modified imaging and diagnostic probes.
-
Bioconjugation: Supports multifunctional linker strategies.
-
Material Science: Functionalizes polymers and nanoparticles with bioorthogonal handles.
Storage and Handling:
-
Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
-
Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid premature hydrolysis of the TFP ester.
This product integrates ultrafast tetrazine ligation with amine-reactive ester chemistry in a long PEG12 scaffold, specifically offering versatility and high solubility for advanced conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
