TCO-PEG12-amine is a versatile bioconjugation reagent with a TCO group and a free amine end. It efficiently links to carboxyl-bearing biomolecules, forming a TCO tag that rapidly conjugates with tetrazine-modified molecules through TCO-tetrazine ligation—a fast, bioorthogonal process widely used in ADCs and other conjugation applications.
Features and Applications:
- Rapid Bioorthogonal Ligation: The TCO group enables ultrafast click chemistry with tetrazine, ideal for precise bioconjugation and ADC development.
- Free Amine End: Conjugates easily with carboxyl-containing molecules, forming stable amide bonds.
- PEG12 Spacer: Enhances solubility, reduces steric hindrance, and stabilizes conjugated molecules, making it suitable for drug delivery and protein modification.
- Synthetic and Stabilizing Agent: Improves solubility and stability of drugs, peptides, and other compounds in complex biological environments.
- Applications:
- ADC Development: Facilitates targeted drug delivery through site-specific conjugation.
- Protein and Peptide Labeling: Used in diagnostics, imaging, and therapeutic applications.
- Surface Modification: Adds antifouling properties to sensors and medical devices.
Summary:
TCO-PEG12-amine combines the speed of TCO-tetrazine click chemistry with enhanced solubility and biocompatibility, making it a key tool in advanced bioconjugation and therapeutic development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
