TCO-PEG11-amine is a versatile bioconjugation reagent featuring a trans-cyclooctene (TCO) group and a free amine end group. It is used to link carboxylic acid-bearing biomolecules, forming a TCO tag that can be conjugated with tetrazine-bearing biomolecules. This TCO-tetrazine ligation is an ultrafast, bioorthogonal process widely employed in antibody-drug conjugates (ADCs) and other conjugation applications.
Key Features and Applications:
- TCO and Amine Groups: The TCO enables rapid, catalyst-free click chemistry with tetrazine, while the amine group allows efficient conjugation to carboxyl-bearing biomolecules.
- PEG11 Spacer: The PEG chain enhances solubility, reduces steric hindrance, and improves biocompatibility, making it suitable for stabilizing drugs and other compounds.
- Applications:
- Bioconjugation: Creates stable, site-specific bonds with proteins, peptides, and other molecules.
- ADC Development: Facilitates ultrafast, targeted conjugation in antibody-drug conjugates.
- Drug Delivery and Imaging: Enhances solubility and stability of labeled compounds in therapeutic and diagnostic applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
