TCO-NHS Acetate
CAS: 1619258-53-5, 1373445-66-9, 1373446-41-3, 1383851-16-8
Description:
TCO-NHS Acetate is a reactive linker that combines a trans-cyclooctene (TCO) group with an NHS (N-hydroxysuccinimide) ester. The TCO group enables rapid, selective “click” reactions with tetrazine-functionalized molecules, while the NHS ester efficiently binds to primary amines on biomolecules. This makes it ideal for precise labeling and bioconjugation.
Key Features:
- TCO Group: Reacts quickly and specifically with tetrazine (Tz) in bioorthogonal “click” reactions, perfect for in vivo applications.
- NHS Ester: Binds to primary amines, allowing covalent attachment of TCO to biomolecules like proteins, peptides, and antibodies.
- Acetate Form: Ensures stability and easy handling during bioconjugation.
Applications:
- Bioconjugation: Commonly used to attach TCO to biomolecules, facilitating selective linkage with Tz-functionalized probes or drugs.
- Bioorthogonal Labeling: Allows precise conjugation in complex biological environments, suitable for live-cell and in vivo imaging.
- In Vivo Imaging and Therapeutics: Enables fast, highly specific targeting of cells or tissues, enhancing drug delivery and diagnostics.
- Protein and Antibody Labeling: Introduces TCO groups to biomolecules for subsequent bioorthogonal chemistry.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
