TCO-carbonylamino-benzamido-PEG1 NHS ester
This product is a heterobifunctional linker with a trans-cyclooctene (TCO) group for ultrafast tetrazine ligation and an NHS ester for amine coupling. The PEG1 spacer adds hydrophilicity and minimal spacing, making it especially useful for compact bioorthogonal labeling and conjugation.
Key Features and Benefits:
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TCO Group: Enables rapid, catalyst-free IEDDA reactions with tetrazines.
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NHS Ester: Couples efficiently with amines to form stable amide bonds.
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PEG1 Spacer: Provides hydrophilicity while maintaining compact design.
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Dual Reactivity: Combines bioorthogonal chemistry with amine coupling.
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High Purity: Ensures reproducibility in sensitive bioconjugation workflows.
Applications:
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Bioorthogonal Labeling: Supports rapid TCO–tetrazine ligation in vitro and in vivo.
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Bioconjugation: Links amine-containing biomolecules while preserving TCO reactivity.
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Probe Development: Useful for compact imaging or diagnostic probes.
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Drug Delivery: Enhances solubility and reactivity in conjugated therapeutics.
Storage and Handling:
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Storage: Store at –20 °C in a tightly sealed, moisture- and light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid prolonged exposure to light to maintain TCO stability.
This product combines ultrafast click reactivity with efficient amine coupling in a compact PEG1 framework, making it especially ideal for targeted conjugation and probe design.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
