t-Butyl-octadecanedioate-NHS ester
t-Butyl-octadecanedioate-NHS ester is a high-purity hydrophobic linker with a C18 diacid backbone, an NHS ester for efficient amine coupling, and a tert-butyl ester for mild acid deprotection to generate a carboxylic acid. Its amphiphilic structure is especially ideal for lipid–polymer conjugation, surface modification, and hydrophobic drug delivery.
Key Features and Benefits
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NHS Ester: Provides efficient coupling with amines to create stable amide bonds.
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t-Butyl Ester Protection: Enables selective, mild acid deprotection for controlled downstream reactions.
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C18 Hydrophobic Backbone: Imparts strong hydrophobicity for membrane interaction, micelle formation, and lipid anchoring.
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Versatile Functionalization: Supports multi-step synthetic workflows.
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High Purity: Supplied at >95% purity for consistent and reproducible performance.
Applications
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Lipid–polymer and amphiphilic molecule synthesis.
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Preparation of hydrophobic drug conjugates.
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Surface functionalization for biosensors or nanoparticles.
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Incorporation into micelles, liposomes, or hydrogels for controlled release.
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Materials engineering for hydrophobic coatings.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as dichloromethane (DCM), DMF, or DMSO; avoid prolonged exposure to moisture to preserve NHS reactivity.
This product is a hydrophobic C18-based linker with an NHS ester for amine coupling and a tert-butyl ester for protected carboxylic acid functionality, especially ideal for lipid conjugation, drug delivery, and material modification applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
