t-Boc-N-Amido-PEG8-amine
t-Boc-N-Amido-PEG8-amine is a high-purity, monodisperse polyethylene glycol (PEG) linker featuring a tert-butoxycarbonyl (t-Boc)–protected amine and a free amine group. The t-Boc group serves as an acid-labile protecting group, enabling controlled deprotection under mild acidic conditions, while the free amine allows immediate conjugation to activated esters or other electrophiles. The PEG8 spacer provides excellent hydrophilicity, flexibility, and extended linker length, making it especially ideal for bioconjugation and surface modification.
Key Features and Benefits
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Dual Amine Functionality: Contains one t-Boc–protected amine for controlled release and one free amine for immediate conjugation.
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PEG8 Spacer: Enhances solubility, reduces aggregation, and improves molecular flexibility.
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High Purity: Supplied at >95% purity for consistent and reproducible coupling efficiency.
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Controlled Reactivity: Acid-labile protection enables sequential modification strategies.
Applications
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Stepwise bioconjugation in peptide, protein, and antibody modification.
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Preparation of multifunctional drug linkers for targeted delivery systems.
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Spacer in surface chemistry and polymer modification.
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Controlled-release strategies in advanced material synthesis.
Storage and Handling
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Storage: Store at –20 °C in a dry, dark environment.
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Handling: Avoid prolonged exposure to moisture and light. Use anhydrous solvents for coupling reactions.
This product is a bifunctional PEG8 linker with one t-Boc–protected amine and one free amine, specifically providing controlled reactivity and excellent hydrophilicity for multi-step bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
