t-Boc-N-Amido-PEG6-NHS ester
This product is a high-purity PEG linker with an NHS ester for efficient amine coupling and a t-Boc–protected amide for selective deprotection specifically under mild acidic conditions. The PEG6 spacer specifically improves solubility, flexibility, and reduces steric hindrance, enabling efficient bioconjugation in aqueous and organic media.
Key Features and Benefits
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NHS Ester – Reacts efficiently with primary amines on proteins, peptides, and other biomolecules.
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t-Boc–Protected Amide – Acid-labile protection allows orthogonal functionalization strategies.
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PEG6 Spacer – Enhances solubility, flexibility, and accessibility of reactive groups.
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Orthogonal Reactivity – Supports sequential and site-specific modifications without cross-reactivity.
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High Purity – Supplied at >95% purity for reliable and reproducible results.
Applications
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Protein, peptide, and small molecule conjugation
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Orthogonal linker design for drug delivery systems
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Multifunctional bioconjugate synthesis
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Surface modification and nanoparticle functionalization
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged moisture exposure to preserve NHS ester reactivity
This product combines efficient amine coupling via NHS ester with selective t-Boc deprotection, linked by a PEG6 spacer for solubility and flexibility, making it especially ideal for orthogonal conjugation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
