t-Boc-N-Amido-PEG5-CH2COOH CAS:890152-41-7 contains a terminal carboxylic acid and Boc-protected amino group. The PEG spacer increases the aqueous solubility of the resulting compound. The terminal carboxylic acid readily reacts with primary and secondary amine under EDC, DCC, HATU or other amide coupling conditions to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine, which can undergo amide coupling with carboxylic acid bearing biomolecules.
t-Boc-N-amido-PEG5-CH2COOH is an amino acid-based polyethylene glycol (PEG) derivative. It is commonly used for the modification of proteins to increase their solubility, stability, and bioavailability. It is synthesized by attaching a protected amino group to an amide bond, followed by attachment of a PEG chain with a carboxylic acid group.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
