t-Boc-N-Amido-PEG4-CH2COOH
This product is a bifunctional PEG4 linker with a Boc-protected amide and a terminal carboxymethyl group. The PEG4 spacer enhances solubility and flexibility, while the Boc group provides acid-labile protection for orthogonal conjugation strategies.
Key Features and Benefits:
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Boc-Protected Amide: Acid-labile group for controlled and selective deprotection.
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Carboxymethyl Group: Reacts efficiently with amines to form stable amide bonds.
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PEG4 Spacer: Improves solubility and reduces steric hindrance in conjugation.
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High Purity: Ensures reproducibility in bioconjugation and synthetic workflows.
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Orthogonal Reactivity: Supports stepwise, multistep synthesis strategies.
Applications:
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Bioconjugation: Enables controlled attachment of biomolecules with PEG spacing.
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Drug Delivery: PEGylated linker improves solubility and pharmacokinetics.
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Surface Modification: Functionalize nanoparticles, hydrogels, or polymers.
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Synthetic Chemistry: Intermediate for constructing PEGylated scaffolds.
Storage and Handling:
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Storage: Store at –20 °C in a dry, light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) to preserve Boc and acid integrity.
This product provides short PEG spacing with Boc protection and a carboxymethyl handle, making it an especially versatile tool for orthogonal conjugation and advanced synthesis.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
