t-Boc-N-amido-PEG10-NHS ester
This product is a heterobifunctional PEG linker containing a Boc-protected amide, a PEG10 spacer, and an NHS ester. It specifically enables orthogonal protection, staged conjugation, and amide coupling, offering solubility, long-chain flexibility, and multifunctional reactivity.
Key Features and Benefits
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Boc-Protected Amide: Allows controlled deprotection for orthogonal conjugation.
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NHS Ester: Couples efficiently with primary amines to form stable amide bonds.
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PEG10 Spacer: Provides solubility, biocompatibility, and extended length.
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Dual Reactivity: Combines protected amide functionality with amine-reactive chemistry.
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High Purity: Ensures reproducibility in sensitive bioconjugation workflows.
Applications
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Bioconjugation: Links PEG scaffolds to biomolecules with orthogonal control.
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Probe Development: Builds multifunctional probes with protected and active handles.
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Drug Delivery: Provides PEG scaffolds with solubility and staged reactivity.
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Organic Synthesis: Serves as an intermediate for modular linker design.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid premature hydrolysis or Boc removal.
This product integrates protected amide chemistry with active NHS ester reactivity in a PEG10 scaffold, specifically enabling flexible and orthogonal conjugation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
