(S,R. S)-AHPC-PEG4-acid CAS:2172820-12-9 is is a protein degrader builiding block used in the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. It contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with acid group. The acid bearing building block can be used parrelly through a formation of amide bond withamine tagged biomolecules to quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand. PEG spacer increase aqueous solubility.
(S,R,S)-AHPC-PEG4-acid is a chemical compound composed of three amino acids (S, R, and S), an alkyl hydroxypropyl carbamate (AHPC) moiety, and a polyethylene glycol (PEG) group with four ethylene oxide units. This compound is used as an excipient to improve the stability of pharmaceuticals.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
