SPDP-Val-Cit-PAB-PNP
This product is a multifunctional cleavable linker combining an SPDP disulfide, a Val-Cit protease-sensitive sequence, a self-immolative PAB spacer, and a reactive PNP ester. Its dual-cleavable design makes it especially useful for ADC development and targeted drug delivery.
Key Features and Benefits
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SPDP Moiety: Introduces a disulfide bond for reductive cleavage and controlled release.
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Val-Cit Linker: Recognized by cathepsin B, enabling tumor-selective drug release.
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PAB Spacer: Ensures self-immolative release of conjugated payloads.
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PNP Ester: Provides a highly reactive leaving group for efficient conjugation.
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High Purity: Manufactured to ≥95% purity for reproducibility in ADC and drug design workflows.
Applications
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Antibody–Drug Conjugates (ADCs): Functions as a dual-cleavable linker for controlled drug release in targeted therapy.
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Bioconjugation: Couples small molecules, peptides, or payloads to biomolecules via activated ester chemistry.
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Drug Delivery Systems: Enables redox- and protease-sensitive release of therapeutics.
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Probe Development: Supports construction of cleavable probes for imaging and mechanistic studies.
Storage and Handling
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Storage: Store at –20 °C in a tightly sealed, light-protected container.
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Handling: Dissolve freshly in dry organic solvent before use; avoid repeated freeze–thaw cycles.
This product combines disulfide and enzymatically cleavable motifs with a self-immolative spacer and reactive ester group, providing an especially powerful platform for ADCs, bioconjugation, and targeted therapeutic research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
