SPDP-PEG12-NHS ester
This product is a heterobifunctional PEG linker containing an NHS ester, a PEG12 spacer, and an SPDP disulfide group. It enables amine conjugation and cleavable disulfide-based release, offering long, flexible spacing for advanced bioconjugation.
Key Features and Benefits
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NHS Ester: Couples efficiently with primary amines to form stable amide bonds.
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SPDP Moiety: Provides a cleavable disulfide bond for controlled release.
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PEG12 Spacer: Improves solubility and extends molecular reach.
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Dual Reactivity: Combines amine coupling with reducible disulfide chemistry.
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High Purity: Ensures reproducible performance in sensitive workflows.
Applications
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Bioconjugation: Links proteins, peptides, or small molecules via amine chemistry.
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Controlled Release: Enables disulfide cleavage under reducing conditions.
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Probe Development: Builds multifunctional probes with cleavable handles.
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Drug Delivery: Provides PEGylated scaffolds with triggered release capability.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid reducing agents before intended cleavage.
This product integrates NHS ester amine conjugation with cleavable disulfide chemistry in a PEG12 scaffold, specifically providing a versatile long-chain linker.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
