SPDMV (Py-ds-dmBut-OSu) is a cleavable linker used in bioconjugation, particularly in the development of antibody-drug conjugates (ADCs). It features a pyridine ring, a disulfide bond, and a 4-methyl-4-(pyridin-2-yldisulfanyl)-pentanoic acid moiety, providing the compound with unique properties for controlled drug release.
Key Features:
- Pyridine Ring: Enhances stability and may influence solubility and binding properties.
- Disulfide Bond (SS): Allows cleavage under reducing conditions, enabling controlled drug release.
- 4-Methyl Group: Offers steric hindrance, increasing selectivity in conjugation reactions.
- OSu Group: Facilitates conjugation with primary amines.
Applications:
- Antibody-Drug Conjugates (ADCs): Links cytotoxic drugs to antibodies, enabling targeted cancer therapy.
- Protein and Peptide Conjugation: Attaches drugs to proteins or peptides for selective drug delivery.
- Drug Delivery Systems: Supports controlled release mechanisms, improving targeted drug delivery.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
