S-Acetylthio-PEG4-NHS (PEG4 SATA or SAT(PEG)4) is a bioconjugation reagent that introduces protected thiol groups to molecules with primary amines. It has an NHS ester for amine binding, a PEG4 spacer to improve solubility and reduce steric hindrance, and an acetyl-protected thiol. This thiol can be deprotected under mild conditions to reveal a free thiol group for further conjugation.
Key Features:
- NHS Ester: Binds efficiently to primary amines for stable conjugation.
- PEG4 Spacer: Enhances solubility and flexibility, reducing steric hindrance.
- Acetyl-Protected Thiol: Enables controlled thiol introduction, with deprotection under mild conditions.
Applications:
- Protein and Peptide Modification: Introduces thiol groups for further conjugation with maleimide compounds.
- Antibody-Drug Conjugates (ADCs): Links cytotoxic drugs to antibodies using thiol-maleimide chemistry.
- Surface Functionalization: Adds thiol groups for biosensor development or biomolecule immobilization.
Store S-Acetylthio-PEG4-NHS at -20°C and dissolve in DCM, THF, acetonitrile, DMF, or DMSO for use.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
