Propargyl-PEG6-thiol
This product is a bifunctional PEG6 linker with a terminal alkyne for click chemistry and a thiol for selective conjugation. The PEG6 spacer specifically provides hydrophilicity and flexibility, making this reagent highly versatile for bioconjugation, drug delivery, and surface modification.
Key Features and Benefits:
-
Propargyl Group: Supports CuAAC or SPAAC click chemistry with azides.
-
Thiol Group: Reacts selectively with maleimides, haloacetyls, or forms disulfides.
-
PEG6 Spacer: Balances hydrophilicity, flexibility, and steric accessibility.
-
High Purity: Ensures reproducibility in sensitive conjugation workflows.
-
Dual Reactivity: Enables orthogonal, stepwise multifunctional conjugation.
Applications:
-
Click Chemistry: Alkyne–azide bioorthogonal labeling for biomolecules and polymers.
-
Bioconjugation: Combine thiol- and alkyne-based reactivities for advanced labeling.
-
Drug Delivery: PEGylated linker enhances solubility and pharmacokinetics.
-
Surface Functionalization: Modify nanoparticles, hydrogels, or polymers with dual reactivity.
Storage and Handling:
-
Storage: Store at –20 °C in a dry, light-protected environment.
-
Handling: Use anhydrous solvents (e.g., DMF, DMSO) and inert atmosphere to preserve alkyne and thiol stability.
This product offers dual thiol and alkyne functionalities with a moderate PEG spacer, making it an especially excellent tool for multifunctional conjugation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
