Propargyl-PEG5-NHS Carbonate
This product is a high-purity heterobifunctional PEG linker featuring a terminal propargyl group for copper-catalyzed azide–alkyne cycloaddition (CuAAC) click chemistry and an N-hydroxysuccinimide (NHS) carbonate ester for efficient coupling to amine-containing molecules. The PEG5 spacer specifically enhances hydrophilicity, increases solubility, and reduces steric hindrance, enabling efficient conjugation in both aqueous and organic systems.
Key Features
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Propargyl group for selective CuAAC click chemistry with azides
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NHS carbonate ester for rapid and efficient amine coupling under mild conditions
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PEG5 spacer improves water solubility, flexibility, and reduces aggregation
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High chemical purity and stability
Applications
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Protein, peptide, and antibody modification via amine coupling and click chemistry
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Preparation of multifunctional bioconjugates
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Nanoparticle and surface functionalization
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Drug delivery systems and biomaterials engineering
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Biosensor and diagnostic reagent development
Storage and Handling
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Store at –20 °C, protected from light and moisture
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Bring to room temperature before opening
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Avoid repeated freeze–thaw cycles
This product contains a propargyl group for CuAAC click chemistry and an NHS carbonate for amine coupling, with a PEG5 spacer specifically for improved solubility and reduced steric hindrance.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.