Propargyl-PEG4-thiol
This product is a bifunctional PEG4 linker with a terminal alkyne for click chemistry and a free thiol for thiol–maleimide or disulfide conjugation. This dual functionality makes it an especially versatile tool for orthogonal bioconjugation, surface functionalization, and drug delivery applications.
Key Features and Benefits:
-
Propargyl Group: Enables CuAAC or SPAAC click chemistry with azides.
-
Thiol Group: Reacts selectively with maleimides, haloacetyls, or forms disulfides.
-
PEG4 Spacer: Provides solubility, flexibility, and reduced steric hindrance.
-
High Purity: Ensures reliable and reproducible conjugation results.
-
Dual Reactivity: Supports orthogonal strategies for multifunctional assemblies.
Applications:
-
Click Chemistry: Alkyne–azide ligation for bioorthogonal labeling.
-
Bioconjugation: Combine thiol and alkyne reactivity in complex conjugates.
-
Surface Modification: Functionalize nanoparticles, hydrogels, or polymers.
-
Drug Delivery: Use as a spacer-linker in targeted therapeutic systems.
Storage and Handling:
-
Storage: Store at –20 °C under inert atmosphere, protected from light.
-
Handling: Use freshly prepared anhydrous solutions to preserve thiol activity.
This product combines click and thiol reactivity in a short PEG spacer, offering an especially compact and versatile linker for advanced bioconjugation workflows.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
