Propargyl-PEG4-NHS carbonate
This product is a high-purity heterobifunctional PEG linker with a terminal propargyl group for copper-catalyzed azide–alkyne cycloaddition (CuAAC) click chemistry and an NHS carbonate ester for efficient amine coupling. The PEG4 spacer specifically enhances solubility, flexibility, and reduces steric hindrance, enabling high-yield conjugations in aqueous and organic systems. This reagent is especially ideal for orthogonal bioconjugation, multifunctional probe synthesis, and surface modification.
Key Features and Benefits
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Propargyl Group: Supports CuAAC click chemistry with azides for selective conjugation.
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NHS Carbonate Ester: Couples efficiently with primary amines to form stable carbamate bonds.
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PEG4 Spacer: Improves solubility and accessibility of reactive groups.
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Heterobifunctional Design: Enables orthogonal, site-specific modifications.
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High Purity: Supplied at >95% purity for reproducibility.
Applications
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Orthogonal labeling of biomolecules.
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Synthesis of multifunctional probes and conjugates.
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Nanoparticle and polymer functionalization.
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Surface modification for biosensors.
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Bioconjugation in drug delivery and diagnostics.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid moisture to maintain NHS carbonate reactivity.
This product combines click-ready propargyl functionality with amine-reactive NHS carbonate chemistry, linked by a PEG4 spacer specifically for solubility and flexibility in bioconjugation and material modification.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.