Propargyl-PEG13-NHS ester is a chemical reagent commonly used in bioconjugation and biomaterials development. This reagent contains a propargyl functional group, a polyethylene glycol (PEG) spacer of 13 units, and an N-hydroxysuccinimide (NHS) ester group, which allows for efficient and selective coupling of the reagent to primary amines in biomolecules.
The propargyl functional group in Propargyl-PEG13-NHS ester can be reacted with complementary azide-containing molecules using a copper-catalyzed click chemistry reaction. This reaction is fast, efficient, and bioorthogonal, allowing for specific labeling and modification of biomolecules in complex biological mixtures.
The PEG13 spacer in this reagent provides hydrophilicity, flexibility, and biocompatibility, which can reduce non-specific interactions with biomolecules and improve the solubility and stability of the bioconjugate. The NHS ester group is a commonly used reactive group for covalent modification of biomolecules, which can be used to create conjugates for imaging, drug delivery, and diagnostics.
Propargyl-PEG13-NHS ester has been used in a variety of biological applications, including the modification of antibodies, enzymes, and proteins, as well as the functionalization of surfaces and biomaterials. This reagent can also be used to create bioorthogonal linkers for the conjugation of multiple biomolecules in a controlled manner.
When working with Propargyl-PEG13-NHS ester, it is important to handle it with care, as it can be potentially hazardous. Proper protective equipment, including gloves and a lab coat, should be worn, and the reagent should be stored according to the manufacturer’s instructions. Additionally, it is important to follow appropriate disposal procedures for the reagent and any materials contaminated with it.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
