Propargyl-PEG1-SS-PEG1-t-butyl ester
This product is a heterobifunctional PEG linker featuring a terminal propargyl group for click chemistry, a cleavable disulfide (SS) bridge, and a tert-butyl–protected ester. The PEG1 spacers provide compact hydrophilicity, while the tBu ester offers acid-labile protection, making this reagent highly versatile for orthogonal and controlled bioconjugation workflows.
Key Features and Benefits:
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Propargyl Group: Supports CuAAC click chemistry with azides.
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Cleavable Disulfide (SS): Enables reductive cleavage under mild conditions for reversible conjugation.
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tBu-Protected Ester: Acid-labile protection for controlled release of carboxyl functionality.
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PEG1 Spacers: Provide compact hydrophilicity and reduced steric hindrance.
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High Purity: Ensures reproducibility in advanced conjugation workflows.
Applications:
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Bioconjugation: Dual-reactive linker for proteins, peptides, and biomolecules.
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Drug Delivery: Enables cleavable linker–payload designs with controlled release.
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Click Chemistry: Azide–alkyne ligation for bioorthogonal conjugation.
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Surface Functionalization: Functionalizes nanoparticles, polymers, and hydrogels.
Storage and Handling:
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Storage: Store at –20 °C in a dry, light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) to preserve alkyne, ester, and disulfide stability.
This product combines click reactivity, cleavable disulfide linkage, and orthogonal protection in a compact PEG framework, making it an especially powerful tool for bioconjugation and drug delivery.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
