Propargyl-PEG1-SS-PEG1-propargyl
This product is a symmetric bifunctional linker containing terminal propargyl (alkyne) groups, short PEG1 spacers, and a central disulfide (SS) bond. The alkynes allow copper-catalyzed (CuAAC) or copper-free click chemistry with azides, while the disulfide provides a cleavable site for reductive release. Its compact PEG1 spacers specifically improve solubility with minimal added length, making it especially useful for controlled and reversible bioconjugation.
Key Features and Benefits
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Terminal Propargyl Groups: Enable efficient CuAAC or SPAAC click reactions with azides.
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Central Disulfide Bond: Cleavable under reducing conditions for controlled release.
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PEG1 Spacers: Provide hydrophilicity and flexibility in a compact design.
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Dual Reactivity: Supports reversible conjugation strategies.
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High Purity: Produced to ≥95% purity for reliable performance.
Applications
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Bioconjugation: Links azide-functionalized biomolecules with a cleavable bridge.
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Drug Delivery: Builds reversible linker systems for targeted release.
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Probe Development: Creates cleavable probes for imaging and diagnostics.
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Organic Synthesis: Serves as a modular intermediate for reversible linkers.
Storage and Handling
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Storage: Store at –20 °C in a sealed, moisture- and light-protected container.
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Handling: Use freshly prepared solutions; avoid repeated freeze–thaw cycles.
This product integrates alkyne click handles with a disulfide bridge in a compact PEG design, specifically offering a powerful tool for reversible conjugation in chemical biology and drug delivery.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
