Phthalamidoxy-PEG2-CH2-ald
This product is a PEG-based linker featuring a phthalimidoxy-protected oxyamine, a PEG2 spacer, and a terminal aldehyde group. It serves as a stable intermediate for controlled deprotection, specifically enabling oxime ligation and aldehyde-based conjugation strategies.
Key Features and Benefits
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Phthalimidoxy Group: Protects oxyamine functionality for controlled release.
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Aldehyde Group: Couples with amines or hydrazides to form stable linkages.
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PEG2 Spacer: Provides solubility while maintaining compact structure.
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Orthogonal Reactivity: Combines protected oxyamine chemistry with aldehyde reactivity.
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High Purity: Ensures reliable performance in sensitive workflows.
Applications
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Bioconjugation: Generates oxyamine linkers for carbonyl–oxime ligation.
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Probe Development: Builds multifunctional probes with aldehyde and oxyamine handles.
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Drug Delivery: Provides PEG scaffolds with reactive aldehyde chemistry.
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Organic Synthesis: Serves as a versatile intermediate for dual-reactive linkers.
Storage and Handling
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Storage: Keep at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.
This product integrates a protected oxyamine with aldehyde functionality in a PEG2 scaffold, specifically offering a versatile intermediate for conjugation and dual-reactive linker synthesis.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
