p-NH₂-Bn-DOTA-tetra(t-Bu ester), CAS Number 446061-19-4, is a versatile bioconjugation compound often used for radiolabeling and imaging in biomedical research. Here’s a brief overview:
Overview
- Full Name: p-Aminobenzyl-DOTA-tetra-tert-butyl ester.
- CAS Number: 446061-19-4.
- Chemical Formula: C33H54N4O8.
- Molecular Weight: 630.8 g/mol.
Key Applications
- Bioconjugation: The amino group (NH₂) allows easy attachment to biomolecules, such as proteins, peptides, or antibodies.
- Radiolabeling: DOTA acts as a strong chelator, binding various metal ions like Gadolinium (Gd) for MRI, or radioactive metals like Gallium-68 (Ga-68) for PET imaging.
- Imaging: Widely used for creating imaging agents suitable for PET, SPECT, and MRI, enhancing diagnostics in biomedical applications.
Properties
- Amino Group (NH₂): Provides a reactive site for covalent bonding to carboxyl or NHS-activated groups, making it a good choice for bioconjugation.
- tert-Butyl Ester Protection: Shields the DOTA’s carboxyl groups during synthesis, ensuring stability until deprotection for chelation.
- Chelating Power: DOTA forms stable complexes with metal ions, boosting the stability and effectiveness of radiolabeled molecules.
Handling and Storage
- Storage: Store in a dry, cool place, away from light to prevent degradation.
- Handling: Wear protective gear to avoid unwanted reactions with sensitive compounds, especially during synthesis.
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