Norbornene-PEG3-Biotin
This product is a multifunctional PEG linker containing a norbornene group, a PEG3 spacer, and a biotin moiety. It enables tetrazine click chemistry and high-affinity streptavidin binding, specifically providing a compact and versatile tool for bioconjugation, probe development, and detection.
Key Features and Benefits
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Norbornene Group: Reacts rapidly with tetrazines via IEDDA click chemistry.
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Biotin Moiety: Provides strong binding affinity to streptavidin and avidin systems.
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PEG3 Spacer: Improves solubility and reduces steric hindrance.
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Dual Reactivity: Combines bioorthogonal click chemistry with affinity capture.
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High Purity: Ensures reproducibility in sensitive conjugation workflows.
Applications
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Bioconjugation: Links tetrazine-modified molecules with biotin-binding partners.
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Probe Development: Builds multifunctional probes for imaging and diagnostics.
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Drug Delivery: Provides scaffolds with click and affinity handles.
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Material Science: Functionalizes nanoparticles, polymers, and surfaces with dual reactivity.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.
This product integrates norbornene click reactivity with biotin–streptavidin binding in a PEG3 scaffold, specifically offering a versatile linker for conjugation and detection.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
