N,N-Bis(PEG2-azide)-N-PEG2-ethanoic acid
This product is a multifunctional PEG-based linker featuring two terminal azides and a carboxylic acid, connected through short PEG2 spacers. The azides enable bioorthogonal click chemistry, while the carboxyl group couples efficiently with amines, making this reagent highly versatile for dual or multivalent bioconjugation and material modification.
Key Features and Benefits:
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Dual Azide Groups: Support CuAAC and SPAAC click chemistry with alkynes.
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Carboxylic Acid Group: Couples with primary amines for stable amide bond formation.
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PEG2 Spacers: Provide hydrophilicity and compact flexibility.
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High Purity: Ensures reproducibility in advanced conjugation workflows.
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Multifunctional Design: Enables orthogonal, multistep conjugation strategies.
Applications:
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Bioconjugation: Facilitates dual azide labeling combined with amide coupling.
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Click Chemistry: Bioorthogonal ligation for proteins, peptides, and polymers.
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Drug Delivery: Enhances solubility and supports multifunctional linker–payload systems.
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Surface Engineering: Functionalizes nanoparticles, hydrogels, and biomaterials.
Storage and Handling:
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Storage: Store at –20 °C, protected from light and moisture.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) to preserve azide and acid reactivity.
This product combines dual azide click handles with a carboxyl group, specifically offering compact PEG spacing for versatile and orthogonal conjugation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
