N,N-Bis(PEG2-azide)-N-amido-PEG2-maleimide
This product is a multifunctional linker featuring dual PEG2-azide groups for click chemistry and a maleimide for thiol-specific conjugation. Its PEG2 spacers enhance solubility and flexibility, making it especially valuable for orthogonal bioconjugation, probe design, and drug delivery.
Key Features and Benefits:
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Dual Azides: Enable CuAAC or SPAAC click chemistry with alkynes.
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Maleimide Group: Reacts selectively with thiols to form stable thioether bonds.
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PEG2 Spacers: Provide hydrophilicity, solubility, and steric accessibility.
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Multifunctional Design: Supports orthogonal, stepwise conjugation.
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High Purity: Ensures reproducibility in advanced workflows.
Applications:
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Bioconjugation: Combines thiol reactivity with dual click handles.
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Probe Development: Builds multifunctional probes for imaging and diagnostics.
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Drug Delivery: Provides dual-reactive linkers for targeted release.
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Synthetic Chemistry: Serves as an intermediate for complex scaffold construction.
Storage and Handling:
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Storage: Store at –20 °C in a sealed, moisture- and light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid hydrolysis of maleimide.
This product integrates dual click-ready azides with thiol-reactive maleimide in a PEG scaffold, specifically offering versatile chemistry for advanced conjugation and drug delivery.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
